Yessayan L, Neyra JA, Canepa-Escaro F, Vasquez-Rios G, Heung M, and Yee J. Effect of hyperchloremia on acute kidney injury in critically ill septic patients: a retrospective cohort study. BMC Nephrol 2017; 18(1):346.
BMC nephrology [electronic resource]
BACKGROUND: Hyperchloremia is common in critically ill septic patients. The impact of hyperchloremia on the incidence of acute kidney injury (AKI) is not well studied. We investigated the association between hyperchloremia and AKI within the first 72 h of intensive care unit (ICU) admission.
METHODS: 6490 ICU adult patients admitted with severe sepsis or septic shock were screened for eligibility. Exclusion criteria included: AKI on admission, baseline estimated glomerular filtration rate (eGFR)/min/1.73 m
RESULTS: A total of 1045 patients were available for analysis following the implementation of eligibility criteria: 303 (29%) had hyperchloremia (Cl
CONCLUSIONS: Hyperchloremia occurs commonly among critically ill septic patients admitted to the ICU, but does not appear to be associated with an increased risk for AKI within the first 72 h of admission.
Medical Subject Headings
Acute Kidney Injury; Aged; Aged, 80 and over; Chlorides; Cohort Studies; Critical Illness; Female; Humans; Intensive Care Units; Male; Middle Aged; Retrospective Studies; Sepsis; Water-Electrolyte Imbalance