Epigenetics in Stroke Recovery

Authors

Haifa Kassis, Henry Ford Health
Amjad Shehadah, Henry Ford Health
Michael Chopp, Henry Ford HealthFollow
Zhenggang Zhang, Henry Ford HealthFollow

Recommended Citation

Kassis H, Shehadah A, Chopp M, and Zhang ZG. Epigenetics in stroke recovery. Genes (Basel) 2017; 8(3).

Document Type

Article

Publication Date

2-27-2017

Publication Title

Genes (Basel)

Abstract

While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be targeted to improve neurological recovery among survivors of stroke is crucial. Epigenetic mechanisms such as post-translational modifications of histone proteins and microRNAs have recently emerged as key regulators of the enhanced plasticity observed during repair processes after stroke. In this review, we highlight the recent advancements in the evolving field of epigenetics in stroke recovery.

PubMed ID

28264471

Volume

8

Issue

3