Cell Treatment for Stroke in Type Two Diabetic Rats Improves Vascular Permeability Measured by MRI

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PLoS One


Treatment of stroke with bone marrow stromal cells (BMSC) significantly enhances brain remodeling and improves neurological function in non-diabetic stroke rats. Diabetes is a major risk factor for stroke and induces neurovascular changes which may impact stroke therapy. Thus, it is necessary to test our hypothesis that the treatment of stroke with BMSC has therapeutic efficacy in the most common form of diabetes, type 2 diabetes mellitus (T2DM). T2DM was induced in adult male Wistar rats by administration of a high fat diet in combination with a single intraperitoneal injection (35mg/kg) of streptozotocin. These rats were then subjected to 2h of middle cerebral artery occlusion (MCAo). T2DM rats received BMSC (5x106, n = 8) or an equal volume of phosphate-buffered saline (PBS) (n = 8) via tail-vein injection at 3 days after MCAo. MRI was performed one day and then weekly for 5 weeks post MCAo for all rats. Compared with vehicle treated control T2DM rats, BMSC treatment of stroke in T2DM rats significantly (p

Medical Subject Headings

Animals; Blood-Brain Barrier; Capillary Permeability; Cell- and Tissue-Based Therapy; Cerebral Hemorrhage; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Magnetic Resonance Imaging; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Stroke

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