The physicochemical variables and interaction forces for the association of dodecyltrimethylammonium bromide plus cefixime trihydrate mixture in aq. short chain alcohols and urea media at different temperatures

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Journal of Molecular Liquids


To develop the drug formulation and reduce antibiotic resistance in the human body, it is essential to study the drug-surfactant interaction. Herein, the interactions between cefixime trihydrate (CMT) and dodecyltrimethylammonium bromide (DTAB) have been evaluated in different experimental situations at a certain range of temperature (300.55–320.55 K) by means of conductivity measurement. The micellar parameters (CMC, degree of counter ion binding (β)) along with some thermodynamic variables like ΔGm0, ΔHm0, and ΔSm0 etc. were evaluated to investigate the interactions between CMT and DTAB. The plot of specific conductivity against surfactant concentration of the DTAB + CMT mixed system was used to determine critical micelle concentration (CMC). The increase of concentration of alcohols (ethanol and 1-propanol) and urea lowers the counterion binding and enhance the CMC values of the DTAB + CMT system. The increase in temperature causes delayed micellization of DTAB + CMT mixture both in aq. alcoholic and urea media. The alteration of CMC values of the DTAB + CMT implies the existence of interaction between DTAB and CMT in the study environment. The micellization of the DTAB + CMT mixed system in all experimental conditions investigated is spontaneous process that has been confirmed by the achieved negative values of ΔGm0. The values of ΔHm0 and ΔSm0 expose the presence of hydrophobic and electrostatic interactions between CMT and DTAB while the contribution of electrostatic interaction is the main force in aq. EtOH medium.