Title

Serum glutamine and hospital-acquired infections after aneurysmal subarachnoid hemorrhage.

Document Type

Article

Publication Date

7-31-2018

Publication Title

Neurology

Abstract

OBJECTIVE: To understand nutritional and inflammatory factors contributing to serum glutamine levels and their relationship to hospital-acquired infections (HAIs) after aneurysmal subarachnoid hemorrhage (SAH).

METHODS: A prospective observational study of patients with SAH who had measurements of daily caloric intake and C-reactive protein, transthyretin, tumor necrosis factor α receptor 1a (TNFαR1a), glutamine, and nitrogen balance performed within 4 preset time periods during the 14 days after SAH. Factors associated with glutamine levels and HAIs were analyzed with multivariable regression. HAIs were tracked daily for time-to-event analyses. Outcome 3 months after SAH was assessed by the Telephone Interview for Cognitive Status and modified Rankin Scale.

RESULTS: There were 77 patients with an average age of 55 ± 15 years. HAIs developed in 18 (23%) on mean SAH day 8 ± 3. In a multivariable linear regression model, negative nitrogen balance (

CONCLUSIONS: Declining glutamine levels in the first 14 days after SAH are influenced by inflammation and associated with an increased risk of HAI.

PubMed ID

29959259

Volume

91

Issue

5

First Page

e421

Last Page

e426

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