Usefulness and Impact of Intraoperative Imaging for Glioma Resection on Patient Outcome and Extent of Resection: A Systematic Review and Meta-Analysis

Document Type

Article

Publication Date

10-19-2019

Publication Title

World Neurosurg

Abstract

BACKGROUND: Diffusion tensor imaging (DTI), functional magnetic resonance imaging (fMRI), and intraoperative magnetic resonance imaging (iMRI) permit greater visualization and more accurate presurgical planning. Meta-analysis of these techniques for maximizing resection, postoperative functionality, and survival may further validate purported strengths of these techniques compared with standard neuronavigation.

METHODS: A systematic search of the PubMed database was conducted in line with the PRISMA guidelines for meta-analysis with the following keywords: "Diffusion tensor imaging" OR "intraoperative MRI" OR "functional MRI" AND "glioma surgery resection outcome." Articles found to meet inclusion criteria were segregated and analyzed and resulting data were compared with standard neuronavigation (control cohort).

RESULTS: A total of 435 articles were identified with 29 distinct studies meeting inclusion criteria including: DTI (n = 3), fMRI (n = 5), iMRI (n = 21). Nine studies directly compared results to standard navigation. Mean GTR rates were not different among cases using DTI, fMRI, iMRI or traditional neuronavigation (p = 0.136). Upon controlling for covariates, more patients received GTR in the advanced imaging cohort, though statistically insignificant (46.5% [95% CI 38.0-55.0%] vs. 30.4% [11.6-49.1%], p = 0.127; Partial eta(2) = 0.217). Patients undergoing advanced imaging demonstrated attenuated incidence of post-surgical permanent neurological deficits, although also statistically insignificant (11.3% vs. 13.8%, p = 0.838).

CONCLUSIONS: Current data are overall insufficient to support the notion that advanced imaging techniques are superior, either as a combined cohort or individually, in achieving GTR, improved symptom resolution, or survival compared with traditional neuronavigation.

PubMed ID

31639502

ePublication

ePub ahead of print

Volume

134

First Page

98

Last Page

110

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