High-grade Oncocytic Tumor (HOT) of Kidney in a Patient with Tuberous Sclerosis Complex.
Trpkov K, Bonert M, Gao Y, Kapoor A, He H, Yilmaz A, Gill AJ, Williamson SR, Comperat E, Tretiakova M, Magi-Galluzzi C, Brimo F, and Hes O. High-grade Oncocytic Tumor (HOT) of Kidney in a Patient with Tuberous Sclerosis Complex. Histopathology 2019; Epub ahead of print.
High-grade oncocytic tumor (HOT) was recently proposed as a novel renal entity that is currently not included in the WHO classification. The first published series by He et al included 14 tumors, collected from multiple institutional files. Recently, Chen et al reported another series of 7 morphologically very similar tumors that they designated "sporadic renal cell carcinomas with eosinophilic and vacuolated cytoplasm". Using Next-generation sequencing they identified somatic inactivating mutations of TSC2 in 3 of 5 tumors tested or activating mutations of MTOR (in 2 of 5 tumors tested). This article is protected by copyright. All rights reserved.
ePub ahead of print