P-selectin expression assay in a repeatedly serotonin-release assay-negative patient with heparin-induced thrombocytopenia
Recommended Citation
Arora K, Rodgers S, Alkhatib Y, Onwubiko IN, Padmanabhan A, and Otrock ZK. P-selectin expression assay in a repeatedly serotonin-release assay-negative patient with heparin-induced thrombocytopenia. Blood Coagul Fibrinolysis 2021.
Document Type
Article
Publication Date
7-12-2021
Publication Title
Blood coagulation & fibrinolysis
Abstract
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate platelets to propagate a hypercoagulable state culminating in life-threatening thrombosis. The serotonin-release assay (SRA) is considered the gold-standard test to diagnose HIT. However, the sensitivity of the SRA was questioned with reported cases of clinical diagnosis of HIT and negative SRA. Herein, we present the utility of platelet factor 4-dependent P-selectin expression assay (PEA) in diagnosing HIT in a patient with thrombocytopenia and recurrent thrombosis who repeatedly tested negative with SRA.
PubMed ID
34261860
ePublication
ePub ahead of print
