Solitary fibrous tumour of the genitourinary tract: A clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene

Authors

E Kouba
N B. Simper
S Chen
Sean R. Williamson, Henry Ford HealthFollow
D J. Grignon
J N. Eble
G T. MacLennan
R Montironi
A Lopez-Beltran
A O. Osunkoya
S Zhang
M Wang
L Wang
T Tran
R E. Emerson
L A. Baldrige
M F. Monn
K Linos
L Cheng

Recommended Citation

Kouba E, Simper NB, Chen S, Williamson SR, Grignon DJ, Eble JN, MacLennan GT, Montironi R, Lopez-Beltran A, Osunkoya AO, Zhang S, Wang M, Wang L, Tran T, Emerson RE, Baldrige LA, Monn MF, Linos K, and Cheng L. Solitary fibrous tumour of the genitourinary tract: A clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene. J Clin Path 2017; 70(6):508-514.

Document Type

Conference Proceeding

Publication Date

2017

Publication Title

J Clin Path

Abstract

Aims To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status. Methods The presence of the molecular hallmark NAB2-STAT6 gene fusion and for the defining fusion partner product STAT6 was assessed in 11 cases of the genitourinary tract solitary fibrous tumours. NAB2-STAT6 gene fusion analysis was performed using a break-apart fluorescence in situ hybridisation (FISH) probe using a probe cocktail with Bacterial artificial chromosome (BAC) clones for STAT6 and NAB2. Results Eleven solitary fibrous tumours were diagnosed in eight male patients and three female patients with a mean age of 46 years (range: 11-64 years). Four of the tumours had malignant histological features, and three were considered moderate risk for metastasis. With a mean follow-up time of 61 months, 1 recurred locally and 2 presented at distant metastatic sites. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion and nuclear STAT6 expression in 58% and 91% of cases, respectively. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between malignant histological features or subsequent clinical outcomes in the genitourinary solitary fibrous tumours. Conclusions A subset of solitary fibrous tumours of the genitourinary tract behaved aggressively. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion in 64% of cases. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between low-risk or high-risk tumours and subsequent clinical outcomes.

Volume

70

Issue

6

First Page

508

Last Page

514