Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
Daya M, Rafaels N, Brunetti TM, Chavan S, Levin AM, Shetty A, Gignoux CR, Boorgula MP, Wojcik G, Campbell M, Vergara C, Torgerson DG, Ortega VE, Doumatey A, Johnston HR, Acevedo N, Araujo M, Avila PC, Belbin G, Bleecker E, Bustamante C, Caraballo L, Cruz A, Dunston GM, Eng C, Faruque MU, Ferguson TS, Figueiredo C, Ford JG, Gan W, Gourraud P, Hansel NN, Hernandez R, Herrera-Paz E, Jiménez S, Kenny E, Knight-Madden J, Kumar R, Lange L, Lange E, Lizee A, Maul P, Maul T, Mayorga A, Meyers D, Nicolae D, O'Connor T, Oliveira R, Olopade C, Olopade O, Qin Z, Rotimi C, Vince N, Watson H, Wilks R, Wilson J, Salzberg S, Ober C, Burchard E, Williams KL, Beaty T, Taub M, Ruczinski I, Mathias R, Barnes K. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nat Commun 2019; 10(1):880.
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12-q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.