Title

Race Differences in Telomere length in benign prostate biopsies and subsequent risk of prostate cancer

Document Type

Article

Publication Date

3-3-2022

Publication Title

Cancer epidemiology, biomarkers & prevention

Abstract

BACKGROUND: Telomere shortening is linked to aging and may be associated with increased risk for cancer. Most cancer studies have used telomere length in leukocytes rather than in the target tissue of cancer origin.

METHODS: A case-control study of 524 case-control pairs with a benign prostate biopsy nested within a historical cohort of 10,478 men was conducted to determine whether pre-malignant prostate telomere length (assessed using a modified quantitative real-time PCR) is associated with prostate cancer risk.

RESULTS: Telomere lengths in benign prostate biopsies of cases vs. controls were similar (1.46 {plus minus} 0.38 vs. 1.45 {plus minus} 0.42; p=0.49). African American (AA) men had significantly shorter telomeres compared with white men (1.51 {plus minus} 0.38 vs. 1.63 {plus minus} 0.39; p<0.0001). In race-stratified analyses, increasing telomere length was more strongly associated with prostate cancer risk in white men, wherein those with telomere length in the highest quartile had 1.9-fold greater adjusted risk of prostate cancer compared to men with prostate telomere lengths in the lowest quartile (OR=1.90; 95% CI = 1.08 - 3.36). Men in the highest telomere length quartile also had a greater risk of aggressive prostate cancer compared with men with telomere lengths in the lowest quartile (OR=2.78; 95% CI =1.25 - 6.19).

CONCLUSION: White men have longer telomeres in benign prostate tissue compared with AA men, and those with the longest telomeres may be at increased risk for prostate cancer, particularly the more aggressive form of the disease.

IMPACT: Race-specific telomere length measures may be an early biomarker of aggressive prostate cancer.

PubMed ID

35247880

ePublication

ePub ahead of print

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