Lokhandwala T, Aly A, Farrelly E, Willey JP, Lamerato LE, Healey M, Coutinho AD, and Seal BS. Management of hepatocellular carcinoma from diagnosis in routine clinical practice. Hepat Oncol 2023; 9(4):Hep45.
AIM: To assess real-world management of patients diagnosed with hepatocellular carcinoma (HCC) within an integrated delivery network.
MATERIALS & METHODS: A retrospective cohort analysis of adults newly diagnosed with HCC from January 2014 to March 2019. Overall survival and treatment journey were assessed over the entire available follow-up period per patient.
RESULTS: Of the 462 patients, 85% had ≥1 treatment. The 24-month overall survival rate (95% CI) from first treatment was 77% (72-82%). Majority of Child-Pugh class A (71%) and B (60%) patients received locoregional therapy first. Half (53.6%) of the patients with liver transplantation first were Child-Pugh class C patients. Sorafenib was the predominant systemic therapy.
CONCLUSION: This integrated delivery network data analysis offers a comprehensive insight into the real-world management of HCC.