Shakaroun DA, Lazar MH, Horowitz JC, and Jennings JH. Serum Ferritin as a Predictor of Outcomes in Hospitalized Patients with Covid-19 Pneumonia. J Intensive Care Med 2022.
Journal of intensive care medicine
Purpose: Elevated ferritin levels are associated with poor outcomes in Covid-19 patients. Optimal timing of ferritin assessment and the merit of longitudinal values remains unclear.
Methods: Patients admitted to Henry Ford Hospital with confirmed SARSCoV-2 were studied. Regression models were used to determine the relation between ferritin and mortality, need for mechanical ventilation, ICU admission, and days on the ventilator.
Results: 2265 patients were evaluated. Patients with an initial ferritin of > 490 ng/mL had an increased risk of death (OR 3.4, P < .001), admission to the ICU (OR 2.78, P < .001) and need for mechanical ventilation (OR 3.9, P < .001). There was no difference between admission and Day 1 ICU ferritin levels (611.5 ng/mL vs. 649 ng/ mL respectively; P=.07). The decline in ferritin over ICU days 1-4 was similar between survivors and non-survivors. A change in ferritin levels from admission to ICU Day 1 (P =.330), or from ICU Day 1 to 2 (P =.788), did not predict days on the ventilator.
Conclusions: Initial Ferritin levels were highly predictive of ICU admission, the need for mechanical ventilation and in-hospital mortality. However, longitudinal measures of ferritin throughout the hospital stay did not provide additional predictive value.