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Background: Cardiac surgery inflicts multiple stressors on the coagulation system, sometimes leading to excessive bleeding post-cardiac surgery and requiring blood component transfusions. Pre-incision treatment with full-dose four-factor prothrombin complex concentrate (4F-PCC) (25 units/kg) has been used satisfactorily in reversing acute periprocedural bleeding time, volume, and associated costs. 4F-PCC poses a substantial cost burden on medical centers, with a cost of approximately $1085 per 500-unit range vial. Purpose: To evaluate the effectiveness of half-dose 4F-PCC (12.5 units/kg) use at Henry Ford Hospital and gain insight into optimal dosing and waste prevention strategies in the operating room.

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Henry Ford Health


Detroit, Michigan


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Project #05: Evaluation of Half-Dose Prothrombin Complex Concentrate in Cardiac Surgery



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