Application of morphometrics as a predictor for survival in female patients with breast cancer spinal metastasis: a retrospective cohort study
Zakaria HM, Massie L, Basheer A, Boyce-Fappiano D, Elibe E, Schultz L, Lee I, Griffith B, Siddiqui F, and Chang V. Application of morphometrics as a predictor for survival in female patients with breast cancer spinal metastasis, a retrospective cohort study. Spine J 2018; Oct;18(10):1798-1803.
The spine journal : official journal of the North American Spine Society
BACKGROUND CONTEXT: The current standard of care for prediction of survival of cancer staging is based on TNM staging. However, for patients with spinal metastasis, who all have identical stage IV disease, identifying accurate prognostic markers of survival would allow better treatment stratification between more aggressive treatment strategies or palliation. Analytical morphometrics enables physicians to quantify patient frailty by measuring lean muscle mass. Morphometrics also predicts survival in patients with lung cancer metastases to the spine.
PURPOSE: Our study evaluates whether morphometrics is predictive of survival in patients with breast cancer spinal metastasis.
DESIGN: This is an observational retrospective cohort study.
PATIENT SAMPLE: This study includes female patients with breast cancer spinal metastases and patients who have undergone stereotactic body radiation therapy.
OUTCOME MEASURES: Overall survival was the primary outcome measure.
METHODS: Morphometric measurements of the psoas muscle were taken using computed tomography scans of the lumbar spine. We then stratified patients into tertiles based on the psoas muscle area.
RESULTS: We identified 118 patients, with a median survival of 104 days (95% confidence interval [CI]=73-157 days). Overall survival was not associated with age, chemotherapy, or number of levels radiated. Patients in the lowest tertile of psoas size had significantly shorter survival compared with the highest tertile (68 days versus 148 days, hazard ratio 1.76 [95% CI=1.08-2.89], p=.024). The shorter survival was also true for the lowest tertile versus the middle tertile (68 days versus 167 days, hazard ratio 1.95 [95% CI=1.19-3.19], p=.007). Kaplan-Meier survival curves were used to visually illustrate the differences in survival between different tertiles.
CONCLUSIONS: Morphometric analysis of the psoas muscle size in patients with breast cancer metastases to the spine was effective in identifying patients at risk of shorter survival. Further research is needed to validate these results, as well as to see if these methodologies can be applied to other cancer histologies.
Medical Subject Headings
Adult; Aged; Aged, 80 and over; Breast Neoplasms; Cohort Studies; Female; Humans; Kaplan-Meier Estimate; Lumbar Vertebrae; Middle Aged; Psoas Muscles; Radiosurgery; Retrospective Studies; Risk Assessment; Spinal Neoplasms; Tomography, X-Ray Computed