Long-term patient report outcomes following radiation therapy for early stage base of tongue carcinoma: A symptom assessment study.

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Conference Proceeding

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Publication Title

Int J Radiat Oncol Biol Phys


Purpose/Objective(s): Given the evolving treatment options and ongoing treatment de-intensification studies for patients with early stage base of tongue carcinoma (BOT), we sought to characterize the long-term patient reported symptoms following modern, standard radiotherapy (RT)-based treatments. Purpose/Objective(s): Disease-free head and neck cancer survivors (>6 months since treatment) were eligible for participation in a questionnaire-based study. Participants completed the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN). Those who had been treated with definitive RT (±systemic therapy) for T1-T2 and 24 months). The top 5 MDASI-HN items rated most severe in terms of mean (±SD) ratings (0-10 scale) were dry mouth (4.42±2.74), difficulty swallowing (2.68±2.77), fatigue (2.39±2.60), problems tasting food (2.23±2.64), and difficulty remembering (2.02±2.11), reported at moderate to severe levels (≥5) by 44, 21, 19, 19, and 15%, respectively. Forty-two % reported none (0) or no more than mild (1-4) symptoms across all 22 MDASI-HN symptom items and 43% had at least one item rated as severe (≥7), with the highest rated items in this group being dry mouth (6.67±2.26) and difficulty swallowing (4.5±3.12). Hierarchal cluster analysis of patients resulted in 3 groups: 1) ∼70%, most of whom had no more than moderate(





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