Long-term patient report outcomes following radiation therapy for early stage base of tongue carcinoma: A symptom assessment study.
Eraj S, Jomaa M, Rock CD, Mohamed ASR, Hutcheson KA, Sturgis EM, Lu C, Morrison WH, Rosenthal DI, Frank SJ, Garden AS, Fuller CD, and Gunn GB. Long-term patient report outcomes following radiation therapy for early stage base of tongue carcinoma: A symptom assessment study. Int J Radiat Oncol Biol Phys 2017; 99(2):E202.
Int J Radiat Oncol Biol Phys
Purpose/Objective(s): Given the evolving treatment options and ongoing treatment de-intensification studies for patients with early stage base of tongue carcinoma (BOT), we sought to characterize the long-term patient reported symptoms following modern, standard radiotherapy (RT)-based treatments. Purpose/Objective(s): Disease-free head and neck cancer survivors (>6 months since treatment) were eligible for participation in a questionnaire-based study. Participants completed the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN). Those who had been treated with definitive RT (±systemic therapy) for T1-T2 and 24 months). The top 5 MDASI-HN items rated most severe in terms of mean (±SD) ratings (0-10 scale) were dry mouth (4.42±2.74), difficulty swallowing (2.68±2.77), fatigue (2.39±2.60), problems tasting food (2.23±2.64), and difficulty remembering (2.02±2.11), reported at moderate to severe levels (≥5) by 44, 21, 19, 19, and 15%, respectively. Forty-two % reported none (0) or no more than mild (1-4) symptoms across all 22 MDASI-HN symptom items and 43% had at least one item rated as severe (≥7), with the highest rated items in this group being dry mouth (6.67±2.26) and difficulty swallowing (4.5±3.12). Hierarchal cluster analysis of patients resulted in 3 groups: 1) ∼70%, most of whom had no more than moderate(