Kalmbach DA, Cheng P, Ahmedani BK, Peterson EL, Reffi AN, Sagong C, Seymour GM, Ruprich MK, and Drake CL. Cognitive-behavioral therapy for insomnia prevents and alleviates suicidal ideation: Insomnia remission is a suicidolytic mechanism. Sleep 2022.
STUDY OBJECTIVES: Insomnia is associated with elevated levels of suicidal thoughts and behaviors. Emerging evidence suggests that cognitive behavioral therapy for insomnia (CBTI) may reduce suicidal ideation (SI). However, the role of digital therapeutics in both the alleviation and prevention of SI remains unclear, and treatment mechanisms facilitating SI reductions have not been clearly identified.
METHOD: 658 adults with DSM-5 insomnia disorder enrolled into a single-site randomized controlled trial evaluating the efficacy of digital CBTI relative to attention control. Outcomes were measured at pretreatment, posttreatment, and 1-year follow-up.
RESULTS: Before treatment, 126 patients endorsed SI (19.1% prevalence). Among those with baseline SI, CBTI patients reported lower SI rates at posttreatment (30.0% vs 54.5%, p=.005) and 1-year follow-up (29.6% vs 46.8%, p=.042) relative to control. PRODCLIN analysis estimated that half of suicidolytic effects of CBTI were mediated through insomnia remission. Among those without baseline SI, CBTI did not directly prevent new onset SI. However, insomnia remitters reported lower rates of new onset SI at posttreatment relative to non-remitters (1.5% vs 6.5%, p=.009). Mediation analysis supported a significant indirect effect wherein CBTI increased likelihood of insomnia remission, which was associated with SI prevention (αβ=-3.13=5, 95%CI=-5.28, -0.96).
CONCLUSION: Digital CBTI reduces insomnia symptoms, which promotes SI alleviation and prevention. For non-suicidal patients, digital CBTI may serve as a highly accessible monotherapy for improving sleep, thereby reducing risk for SI. For suicidal patients, digital CBTI may be appropriately administered as an adjunct treatment to support mainline intervention more directly targeting suicidogenic thoughts.
ePub ahead of print