Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies
Kandagatla P, Maguire LH, and Hardiman KM. Biology of nodal spread in colon cancer: Insights from molecular and genetic studies. Eur Surg Res 2018; 59(5-6):361-370.
European Surgical Research
Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy.
Medical Subject Headings
Colonic Neoplasms; DNA Copy Number Variations; Genetic Heterogeneity; Humans; Lymphatic Metastasis; Mutation; Proto-Oncogene Proteins p21(ras); Whole Genome Sequencing