Title

Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies.

Document Type

Article

Publication Date

1-1-2018

Publication Title

European Surgical Research

Abstract

Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy.

Medical Subject Headings

Colonic Neoplasms; DNA Copy Number Variations; Genetic Heterogeneity; Humans; Lymphatic Metastasis; Mutation; Proto-Oncogene Proteins p21(ras); Whole Genome Sequencing

PubMed ID

30537705

Volume

59

Issue

5-6

First Page

361

Last Page

370

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