Breast Cancer Disparities: How Can We Leverage Genomics to Improve Outcomes?
Davis MB, and Newman LA. Breast cancer disparities: How can we leverage genomics to improve outcomes? Surg Oncol Clin N Am 2018; 27(1):217-234.
Surgical oncology clinics of North America
Breast cancer mortality rates are higher in African American compared with white American women. Disproportionately rising incidence rates, coupled with higher rates of biologically aggressive disease among African Americans is resulting in a widening of the mortality disparity. Higher rates of triple-negative breast cancer among African American women, as well as women from western sub-Saharan Africa, has prompted questions regarding the role of African ancestry as a marker of hereditary susceptibility for specific disease phenotypes. Advances in germline genetics, as well as somatic tumor genomic research, hold great promise in the effort to understand the biology of breast cancer variations between different population subsets.
Medical Subject Headings
African Americans; Breast Neoplasms; European Continental Ancestry Group; Female; Genomics; Healthcare Disparities; Humans