Impact of OCS Lung Warm Perfusion Times on Post-Transplant Survival - "Real-World" Experience from Thoracic Organ Perfusion (TOP) Registry

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Conference Proceeding

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Publication Title

J Heart Lung Transplant


Purpose: The TOP registry is a multi-center, all-inclusive observational registry that was established to collect perfusion parameters and post-transplant clinical outcomes for lung transplants performed with donor lungs perfused and assessed on the OCS Lung system. The current report establishes the association between OCS Lung warm perfusion time and post-transplant survival in the initial TOP Registry cohort.

Methods: We evaluated the impact of OCS Lung perfusion time on post-transplant survival in the TOP Registry patient cohort to discern any clinical correlation. We defined 3 clinically relevant time points to analyze. Group A: ≤6 hours of OCS perfusion, Group B: 6-12 hours of OCS perfusion, and Group C: >12 hours of OCS perfusion.

Results: Data from 262 OCS lung transplant recipients in the registry were available for analysis. Of these, 70 were standard criteria lungs, 137 were extended criteria including DCD lungs, and 55 were characterized as “other” including single lung, retransplants and multi-organ transplants. There were 129 patients in Group A, 117 patients in Group B, and 12 patients in Group C. The 1-year survival, probability was 83.7% in Group A, 82% in Group B, and 87.5% in Group C Log-rank (p= 0.793 - Figure 1).

Conclusion: OCS Lung system perfusion times were associated with good post-transplant survival even when extended beyond 12 hours. This finding has two important clinical implications: (1) the OCS Lung can be utilized to transport and preserve donor lungs from outside the recipients’ standard acceptance radius; and (2) the OCS Lung can be used to perfuse the donor lungs overnight to better manage transplant procedure logistics.





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