The Association between Mortality and Distance to Treatment Facility in Patients with Muscle Invasive Bladder Cancer.
Ryan S, Serrell EC, Karabon P, Mills G, Hansen M, Hayn M, Menon M, Trinh QD, Abdollah F, and Sammon JD. The association between mortality and distance to treatment facility in patients with muscle invasive bladder cancer. J Urol 2017; 199(2):424-429.
The Journal of urology
PURPOSE: Regionalization of bladder cancer treatment is suggested to improve quality of care. As an unintended consequence some patients travel farther for care with unknown implications on outcomes. We characterized the relationship between distance and overall mortality in patients with invasive bladder cancer and those who underwent radical cystectomy.
MATERIALS AND METHODS: We performed a retrospective cohort study using NCDB (National Cancer Database) from 2004 to 2012 to identify patients with muscle invasive bladder cancer (cT2a-T4 N0 M0). We also extracted a subgroup of patients who underwent radical cystectomy. Multivariate Cox proportional hazards and multinomial logistic regression analyses were performed in each group, controlling for demographic, clinical, hospital and geographic factors.
RESULTS: For 34,729 patients with muscle invasive bladder cancer traveling farther for treatment was associated with a lower probability of overall mortality (referent less than 12.5 miles, 12.5 to 49.9 miles HR 0.96, 95% CI 0.92-0.99 and 50 to 249.9 miles HR 0.91, 95% CI 0.86-0.96). This was significant for patients with cT2 disease and those treated at academic centers (p ≤0.05). For 11,059 patients who underwent radical cystectomy this trend did not reach significance. However, longer distance was associated with surgery at a high volume institution and receipt of neoadjuvant chemotherapy (each p <0.001).
CONCLUSIONS: Patients who traveled farther for bladder cancer treatment did not experience inferior survival outcomes and traveling to academic institutions was associated with reduced mortality. For patients who undergo cystectomy this relationship was equivocal, although longer distance was associated with receiving neoadjuvant chemotherapy or surgery at a high volume facility. These findings may reflect a complex association of regionalization of bladder cancer care with patient individual health and health care seeking behavior.
Medical Subject Headings
Academic Medical Centers; Adult; Aged; Aged, 80 and over; Carcinoma, Transitional Cell; Cystectomy; Female; Follow-Up Studies; Health Services Accessibility; Hospitals, High-Volume; Humans; Logistic Models; Male; Middle Aged; Proportional Hazards Models; Registries; Retrospective Studies; Risk Factors; United States; Urinary Bladder Neoplasms