Document Type


Publication Date


Publication Title

J Sex Med


BACKGROUND: Men who contract coronavirus disease 2019 (COVID-19) appear to have worse clinical outcomes compared with women which raises the possibility of androgen-dependent effects.

AIM: We sought to determine if testosterone replacement therapy (TRT) is associated with worse clinical outcomes.

METHODS: Through a retrospective chart review, we identified 32 men diagnosed with COVID-19 and on TRT. They were propensity score matched to 63 men diagnosed with COVID-19 and not on TRT. Data regarding comorbidities and endpoints such as hospital admission, intensive care unit admission, ventilator utilization, thromboembolic events, and death were extracted. Chi-square and Kruskal-Wallis tests examined differences in categorical and continuous variables, respectively. Logistic regression analysis tested the relationship between TRT status and the study endpoints.

RESULTS: There were no statistically significant differences between the 2 groups, and TRT was not a predictor of any of the endpoints on multivariate analysis.

CONCLUSION: These results suggest that TRT is not associated with a worse clinical outcome in men diagnosed with COVID-19.

Medical Subject Headings

COVID-19; Hormone Replacement Therapy; Humans; Hypogonadism; Male; Retrospective Studies; SARS-CoV-2; Testosterone

PubMed ID






First Page


Last Page




To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.