Rambhatla A, Bronkema CJ, Corsi N, Keeley J, Sood A, Affas Z, Dabaja AA, Rogers CG, Liroff SA, and Abdollah F. COVID-19 Infection in Men on Testosterone Replacement Therapy. J Sex Med 2021; 18(1):215-218.
J Sex Med
BACKGROUND: Men who contract coronavirus disease 2019 (COVID-19) appear to have worse clinical outcomes compared with women which raises the possibility of androgen-dependent effects.
AIM: We sought to determine if testosterone replacement therapy (TRT) is associated with worse clinical outcomes.
METHODS: Through a retrospective chart review, we identified 32 men diagnosed with COVID-19 and on TRT. They were propensity score matched to 63 men diagnosed with COVID-19 and not on TRT. Data regarding comorbidities and endpoints such as hospital admission, intensive care unit admission, ventilator utilization, thromboembolic events, and death were extracted. Chi-square and Kruskal-Wallis tests examined differences in categorical and continuous variables, respectively. Logistic regression analysis tested the relationship between TRT status and the study endpoints.
RESULTS: There were no statistically significant differences between the 2 groups, and TRT was not a predictor of any of the endpoints on multivariate analysis.
CONCLUSION: These results suggest that TRT is not associated with a worse clinical outcome in men diagnosed with COVID-19.
Medical Subject Headings
COVID-19; Hormone Replacement Therapy; Humans; Hypogonadism; Male; Retrospective Studies; SARS-CoV-2; Testosterone