miR-183-96-182 Cluster Is Involved in Invariant NKT Cell Development, Maturation, and Effector Function

Authors

Jie Wang, Henry Ford HealthFollow
Guihua Li, Henry Ford Health
Xiaojun Wu, Henry Ford HealthFollow
Queping Liu, Henry Ford Health
Congcong Yin, Henry Ford HealthFollow
Stephen L. Brown, Henry Ford HealthFollow
Shunbin Xu
Qing-Sheng Mi, Henry Ford HealthFollow
Li Zhou, Henry Ford HealthFollow

Recommended Citation

Wang J, Li G, Wu X, Liu Q, Yin C, Brown SL, Xu S, Mi QS, and Zhou L. miR-183-96-182 Cluster Is Involved in Invariant NKT Cell Development, Maturation, and Effector Function. J Immunol 2019.

Document Type

Article

Publication Date

12-15-2019

Publication Title

Journal of immunology

Abstract

The development, differentiation and function of invariant NKT (iNKT) cells require a well-defined set of transcription factors, but how these factors are integrated to each other and the detailed signaling networks remain poorly understood. Using a Dicer-deletion mouse model, our previous studies have demonstrated the critical involvement of microRNAs (miRNAs) in iNKT cell development and function, but the role played by individual miRNAs in iNKT cell development and function is still not clear. In this study, we show the dynamic changes of miRNA 183 cluster (miR-183C) expression during iNKT cell development. Mice with miR-183C deletion showed a defective iNKT cell development, sublineage differentiation, and cytokine secretion function. miRNA target identification assays indicate the involvement of multiple target molecules. Our study not only confirmed the role of miR-183C in iNKT cell development and function but also demonstrated that miR-183C achieved the regulation of iNKT cells through integrated targeting of multiple signaling molecules and pathways.

PubMed ID

31748350

ePublication

ePub ahead of print

Volume

203

Issue

12

First Page

3256

Last Page

3267