miR-183-96-182 Cluster Is Involved in Invariant NKT Cell Development, Maturation, and Effector Function
Recommended Citation
Wang J, Li G, Wu X, Liu Q, Yin C, Brown SL, Xu S, Mi QS, and Zhou L. miR-183-96-182 Cluster Is Involved in Invariant NKT Cell Development, Maturation, and Effector Function. J Immunol 2019.
Document Type
Article
Publication Date
12-15-2019
Publication Title
Journal of immunology
Abstract
The development, differentiation and function of invariant NKT (iNKT) cells require a well-defined set of transcription factors, but how these factors are integrated to each other and the detailed signaling networks remain poorly understood. Using a Dicer-deletion mouse model, our previous studies have demonstrated the critical involvement of microRNAs (miRNAs) in iNKT cell development and function, but the role played by individual miRNAs in iNKT cell development and function is still not clear. In this study, we show the dynamic changes of miRNA 183 cluster (miR-183C) expression during iNKT cell development. Mice with miR-183C deletion showed a defective iNKT cell development, sublineage differentiation, and cytokine secretion function. miRNA target identification assays indicate the involvement of multiple target molecules. Our study not only confirmed the role of miR-183C in iNKT cell development and function but also demonstrated that miR-183C achieved the regulation of iNKT cells through integrated targeting of multiple signaling molecules and pathways.
PubMed ID
31748350
ePublication
ePub ahead of print
Volume
203
Issue
12
First Page
3256
Last Page
3267