Longitudinal Characterization of Atopic Dermatitis Phenotypes in The Children's Respiratory and Environmental Workgroup (CREW) Birth Cohort Consortium

Authors

Alexandra R. Sitarik, Henry Ford HealthFollow
Jocelyn Biagini
Amy A. Eapen, Henry Ford HealthFollow
Daniel Jackson
Christine L. M Joseph, Henry Ford HealthFollow
Haejin Kim, Henry Ford HealthFollow
Lisa Martin
Katherine Rivera-Spoljaric
Eric Schauberger
Ganesa Wegienka, Henry Ford HealthFollow
James Gern
Anne M. Singh

Recommended Citation

Sitarik A, Biagini J, Eapen A, Jackson D, Joseph C, Kim H, Martin L, Rivera-Spoljaric K, Schauberger E, Wegienka G, Gern J, and Singh AM. Longitudinal Characterization of Atopic Dermatitis Phenotypes in The Children's Respiratory and Environmental Workgroup (CREW) Birth Cohort Consortium. J Allergy Clin Immunol 2023; 151(2):AB145.

Document Type

Conference Proceeding

Publication Date

2-1-2023

Publication Title

J Allergy Clin Immunol

Abstract

Rationale: Previously identified longitudinal patterns of atopic dermatitis (AD) may lack generalizability and precision due to small sample size and limited time points. We identify and describe longitudinal AD phenotypes in a large consortium study.

Methods: Data from 11 birth cohorts across the United States from the CREW (Children’s Respiratory and Environmental Workgroup) consortium were harmonized to determine physician diagnosis of AD in each year of life from 0-7 years of age (N=7,900). AD phenotypes were identified using Longitudinal Latent Class Analysis, and relationships with demographic variables were determined using multinomial logistic regression with a 3-step procedure to account for uncertainty in class membership.

Results: We identified 5 classes of AD expression, selected based on model fit, interpretability, and clinical utility: Persistent AD (15.4%), Early AD with Potential Reoccurrence (2.7%), Late-Onset AD (7.0%), Transient Early AD (3.0%), and Minimal/No AD (72.0%). Males had significantly higher odds of Persistent AD (OR [95% CI]=1.47 [1.22, 1.75]) and Early AD with Potential Reoccurrence (OR [95% CI]=1.89 [1.19, 2.94]). Relative to White children, Black children had higher odds of Persistent AD (OR [95% CI]=2.50 [2.05, 3.05]), Early AD with Potential Reoccurrence (OR [95% CI]=3.07 [1.94, 4.85]), and Transient Early AD (OR [95% CI]=4.12 [2.62, 6.48]).

Conclusions: Five AD phenotypes exist in a diverse national sample of children. Black children and males are at increased risk of early and persistent AD. These findings illustrate potential risk factors to target AD prevention.

Volume

151

Issue

2

First Page

AB145