Social Determinants of Health Associated With Healthcare Resource Utilization in Hereditary Angioedema

Document Type

Conference Proceeding

Publication Date

2-10-2026

Publication Title

J Allergy Clin Immunol

Keywords

dipeptidyl carboxypeptidase inhibitor, angioneurotic edema, Caucasian, child, complement system, conference abstract, congenital disorder, controlled study, diagnosis, drug therapy, emergency department visit, ethnicity, familial disease, female, highest income group, Hispanic, hospitalization, human, lowest income group, major clinical study, male, patient care, prescription, social determinants of health, suburban area, United States

Abstract

Rationale: Hereditary angioedema (HAE) is a rare inherited disorder characterized by unpredictable swelling attacks. Patient care can be impacted by social determinants of health. Methods: US patients from Inovalon’s closed claims database with ≥2 medical claims (D84.1 complement system or T783XXX angioedema) and ≥1 prescription for HAE medication were screened between 1/1/2017–9/30/2021 (first claim as index date). Eligible patients had 12 months’ continuous enrollment in a health plan pre- and 24 months post-index without a pre-index documented history of HAE or evidence of angiotensin-converting enzyme inhibitor use after diagnosis. Race/ethnicity, income, and rurality were analyzed to understand differences in healthcare resource utilization (HCRU). Results: In multivariable models adjusting for age and sex, Black and Hispanic patients had a 133% and 71% higher rate of HAE-related emergency department (ED) visits than White patients (rate ratio [RR; 95% CI]: 2.33 [1.74–3.13] and 1.71 [1.16–2.50], respectively), while Black patients also had a greater rate of HAE-related hospitalizations vs White patients (RR [95% CI]: 2.25 [1.10–4.57]). Low-income (<$50K) patients had a 78% higher rate of HAE-related ED visits than high-income (≥$50K) patients (RR [95% CI]: 1.78 [1.37–2.31]) with no differences in hospitalizations (RR [95% CI]: 0.93 [0.49–1.78]). There were no significant differences in HAE-related HCRU between patients who lived in rural vs urban/suburban environments. Conclusions: This study suggests disparities in healthcare outcomes exist based on race/ethnicity and income among patients making their first claim for HAE. Additional patient-centric research within HAE communities is needed to improve health equity.

Volume

157

Issue

2

First Page

AB75

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