Patient-Reported Disease Control, Work Productivity, and Activity Impairment in Hereditary Angioedema: Insights from OASIS-HAE

Document Type

Conference Proceeding

Publication Date

2-10-2026

Publication Title

J Allergy Clin Immunol

Keywords

donidalorsen, placebo, absenteeism, adult, angioneurotic edema, conference abstract, controlled study, diagnosis, disease control, drug therapy, effect size, human, male, post hoc analysis, presenteeism, questionnaire, student engagement

Abstract

Rationale: Patients with hereditary angioedema (HAE) experience recurrent episodes of severe swelling, which impair work/school engagement and impact productivity. This study evaluated the relationship between patient-reported HAE disease control and work/school productivity and activities. Better disease control was hypothesized to be associated with less work and activity impairment. Methods: Post hoc analyses of the 24-week, Phase 3 OASIS-HAE study (NCT05139810) of donidalorsen versus placebo (n=90, pooled sample) were conducted. HAE control was measured using the Angioedema Control Test (AECT), scored 0 to 16; higher scores indicate better control. Subgroups were defined at Week 24: 1) poorly- versus well-controlled (AECT<10 versus AECT≥10), and 2) less-than-complete versus complete control (AECT<16 versus AECT=16). Impact on work and activities was measured using the Work Productivity and Activity Impairment plus Classroom Impairment Questionnaire (WPAI+CIQ), which assesses absenteeism, presenteeism, and impairment in overall productivity and activities. Mean WPAI+CIQ score differences across subgroups were evaluated using t-tests and associated effect sizes (Cohen’s d). Results: Significant differences in work and activity impairment were observed across disease control subgroups for all WPAI+CIQ domains except absenteeism. Very large effect sizes were observed for patients with well-controlled disease, who reported less productivity loss and activity impairment than those with poorly controlled disease (all p<0.05; all d>1.80). Similar findings were observed among patients with complete disease control, but effect sizes were moderate compared to less-than-complete controlled disease (all p<0.05; d=0.57 to 0.76). Conclusions: Patients in OASIS-HAE who achieved well- or completely controlled disease experienced significantly fewer impacts on work/school productivity and activities.

Volume

157

Issue

2

First Page

AB51

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