Association between intravenous 5 % albumin administration and acute kidney injury after partial nephrectomy. A retrospective study
Recommended Citation
Guerra-Londoño JJ, Moreno-Lopez SM, Gundre S, Jehanzeb A, Wong R, Cortes-Mejia N, Bejarano-Ramirez D, Mensah CKB, and Cata JP. Association between intravenous 5 % albumin administration and acute kidney injury after partial nephrectomy. A retrospective study. J Clin Anesth 2025; 104:111873.
Document Type
Article
Publication Date
6-1-2025
Publication Title
Journal of clinical anesthesia
Abstract
BACKGROUND: Acute kidney injury (AKI) after partial nephrectomy is a frequent postoperative complication that can affect nearly half of patients, according to various studies. In the current study, we investigated the association of intraoperative administration of 5 % albumin, compared with crystalloids alone, with AKI after partial nephrectomy.
METHODS: This single-center retrospective study included adult patients undergoing partial nephrectomy. The primary endpoint was AKI within 72 h after surgery using the KIDGO definition. Secondary endpoints were time-to-AKI, reoperations, AKI severity and length of hospital stay. We used propensity score-based nearest-neighbor methods balance the patient baseline characteristics.
RESULTS: A total of 1688 patients were included in the analysis, with 809 receiving 5 % albumin and 879 in the control group. After matching, 729 patients received 5 % albumin, while 674 were controls. The incidence of acute kidney injury (AKI) was significantly higher in the 5 % albumin group (32.78 %) compared to the control group (25.51 %). Multivariate analysis revealed that receiving 5 % albumin was associated with a 32 % increased risk of developing AKI. Furthermore, the analysis indicated that this association was dose-dependent.
CONCLUSION: Our study suggests that intraoperative administration of 5 % albumin may not be a risk factor for AKI after partial nephrectomy. Given the discrepancy between these results and previous studies, a future prospective randomized controlled trial is needed to confirm our findings.
Medical Subject Headings
Humans; Acute Kidney Injury; Retrospective Studies; Male; Female; Middle Aged; Nephrectomy; Postoperative Complications; Aged; Risk Factors; Propensity Score; Intraoperative Care; Length of Stay; Incidence; Albumins; Adult; Crystalloid Solutions
PubMed ID
40373496
Volume
104
First Page
111873
Last Page
111873
