Mania induced by tramadol-venlafaxine combination
Recommended Citation
Hefzi N, Grekin J, and Ahmed A. Mania induced by tramadol-venlafaxine combination. J Opioid Manag 2019; 15(4):342-344.
Document Type
Article
Publication Date
7-1-2019
Publication Title
J Opioid Manag
Abstract
A 49-year-old male with major depressive disorder well-managed with venlafaxine [serotonin and norepinephrine reuptake inhibitor (SNRI)] and no history of manic episodes developed his first manic episode following use of tramadol. Tramadol-induced mania has been described with selective serotonin reuptake inhibitors but not SNRIs. In addition, mania is not listed as a potential clinical side effect-further illustrating this relative rarity. Due to tramadol's SNRI activity, there is definitive risk for mood lability in individuals managed with tramadol and other serotonergic medications as seen in this patient. The authors findings suggest the need for greater risk consideration when prescribing tramadol with other related agents such as venlafaxine.
Medical Subject Headings
Analgesics, Opioid; Bipolar Disorder; Depressive Disorder, Major; Humans; Male; Middle Aged; Serotonin Uptake Inhibitors; Tramadol; Venlafaxine Hydrochloride
PubMed ID
31637686
Volume
15
Issue
4
First Page
342
Last Page
344
