Integrated Ultrasound and Photoacoustic-Guided Laser Ablation Theranostic Endoscopic System

Document Type

Article

Publication Date

2022

Publication Title

IEEE transactions on bio-medical engineering

Abstract

Advancements in ablation techniques have paved the way towards the development of safer and more effective clinical procedures for treating various maladies such as atrial fibrillation (AF). AF is characterized by rapid, chaotic atrial activation and is commonly treated using radiofrequency applicators or laser ablation catheters. However, the lack of thermal lesion formation and temperature monitoring capabilities in these devices prevents them from measuring the treatment outcome directly. In addition, poor differentiation between healthy and ablated tissues leads to incomplete ablation, which reduces safety and causes complications in patients. Hence, a novel photoacoustic (PA)-guided laser ablation theranostic device was developed around a traditional phased-array endoscope. The proposed technology provides lesion formation, tissue distinguishing, and temperature monitoring capabilities. Our results have validated the lesion monitoring capability of the proposed technology through PA correlation maps. The tissue distinguishing capability of the theranostic device was verified by the measurable differences in the PA signal between pre-and post-ablated mice myocardial tissue. The increase in the PA signal with temperature variations caused by the ablation laser confirmed the ability of the proposed device to provide temperature feedback.

Medical Subject Headings

Animals; Mice; Precision Medicine; Endoscopy; Heart Atria; Atrial Fibrillation; Laser Therapy; Treatment Outcome; Catheter Ablation; Pulmonary Veins

PubMed ID

35724291

Volume

70

Issue

1

First Page

67

Last Page

75

Find It @ Sladen

Share

COinS