"Clinical characteristics and outcomes of alcohol septal ablation in th" by Pedro Engel Gonzalez, Samuel Gregerson et al.
 

Clinical characteristics and outcomes of alcohol septal ablation in the era of transcatheter valve interventions

Document Type

Article

Publication Date

5-1-2024

Publication Title

Catheterization and cardiovascular interventions

Abstract

BACKGROUND: The clinical efficacy and safety of alcohol septal ablation (ASA) for obstructive hypertrophic cardiomyopathy (HCM) have been well-established; however, less is known about outcomes in patients undergoing preemptive ASA before transcatheter mitral valve replacement (TMVR).

AIMS: The goal of this study is to characterize the procedural characteristics and examine the clinical outcomes of ASA in both HCM and pre-TMVR.

METHODS: This retrospective study compared procedural characteristics and outcomes in patient who underwent ASA for HCM and TMVR.

RESULTS: In total, 137 patients were included, 86 in the HCM group and 51 in the TMVR group. The intraventricular septal thickness (mean 1.8 vs. 1.2 cm; p < 0.0001) and the pre-ASA LVOT gradient (73.6 vs. 33.8 mmHg; p ≤ 0.001) were higher in the HCM group vs the TMVR group. The mean volume of ethanol injected was higher (mean 2.4 vs. 1.7 cc; p < 0.0001). The average neo-left ventricular outflow tract area increased significantly after ASA in the patients undergoing TMVR (99.2 ± 83.37 mm(2) vs. 196.5 ± 114.55 mm(2); p = <0.0001). The HCM group had a greater reduction in the LVOT gradient after ASA vs the TMVR group (49.3 vs. 18 mmHg; p = 0.0040). The primary composite endpoint was higher in the TMVR group versus the HCM group (50.9% vs. 25.6%; p = 0.0404) and had a higher incidence of new permanent pacemaker (PPM) (25.5% vs. 18.6%; p = 0.3402). The TMVR group had a higher rate of all-cause mortality (9.8% vs. 1.2%; p = 0.0268).

CONCLUSIONS: Preemptive ASA before TMVR was performed in patients with higher degree of clinical comorbidities, and correspondingly is associated with worse short-term clinical outcomes in comparison to ASA for HCM patients. ASA before TMVR enabled percutaneous mitral interventions in a small but significant minority of patients that would have otherwise been excluded. The degree of LVOT and neoLVOT area increase is significant and predictable.

Medical Subject Headings

Humans; Retrospective Studies; Male; Ethanol; Cardiomyopathy, Hypertrophic; Female; Treatment Outcome; Ablation Techniques; Aged; Cardiac Catheterization; Middle Aged; Risk Factors; Heart Valve Prosthesis Implantation; Time Factors; Mitral Valve; Recovery of Function; Aged, 80 and over; Heart Septum; Mitral Valve Insufficiency

PubMed ID

38639143

Volume

103

Issue

6

First Page

1023

Last Page

1034

Share

COinS