Early vs. delayed mechanical circulatory support in patients with acute myocardial infarction and cardiogenic shock

Document Type

Article

Publication Date

5-28-2024

Publication Title

Eur Heart J Acute Cardiovasc Care

Abstract

AIMS: Despite increased temporary mechanical circulatory support (tMCS) utilization for acute myocardial infarction complicated by cardiogenic shock (AMI-CS), data regarding efficacy and optimal timing for tMCS support are limited. This study aimed to describe outcomes based on tMCS timing in AMI-CS and to identify predictors of 30-day mortality and readmission.

METHODS AND RESULTS: Patients with AMI-CS identified in the National Readmissions Database were grouped according to the use of tMCS and early (<24 >h) vs. delayed (≥24 h) tMCS. The correlation between tMCS timing and inpatient outcomes was evaluated using linear regression. Multivariate logistic regression was used to identify variables associated with 30-day mortality and readmission. Of 294 839 patients with AMI-CS, 109 148 patients were supported with tMCS (8067 veno-arterial extracorporeal membrane oxygenation, 33 577 Impella, and 79 161 intra-aortic balloon pump). Of patients requiring tMCS, patients who received early tMCS (n = 79 906) had shorter lengths of stay (7 vs. 15 days, P < 0.001) and lower rates of ischaemic and bleeding complications than those with delayed tMCS (n = 32 241). Patients requiring tMCS had higher in-hospital mortality [odds ratio (95% confidence interval)] [1.7 (1.7-1.8), P < 0.001]. Among patients requiring tMCS, early support was associated with fewer complications, lower mortality [0.90 (0.85-0.94), P < 0.001], and fewer 30-day readmissions [0.91 (0.85-0.97), P = 0.005] compared with patients with delayed tMCS.

CONCLUSION: Among patients receiving tMCS for AMI-CS, early tMCS was associated with fewer complications, shorter lengths of stay, lower hospital costs, and fewer deaths and readmissions at 30 days.

Medical Subject Headings

Humans; Shock, Cardiogenic; Male; Female; Myocardial Infarction; Extracorporeal Membrane Oxygenation; Middle Aged; Hospital Mortality; Heart-Assist Devices; Aged; Intra-Aortic Balloon Pumping; Retrospective Studies; Time Factors; Patient Readmission; United States; Treatment Outcome; Survival Rate; Length of Stay; Follow-Up Studies

PubMed ID

38502888

ePublication

ePub ahead of print

Volume

13

Issue

5

First Page

390

Last Page

397

Find It @ Sladen

Share

COinS