Diabetic Cardiomyopathy: What Clinicians Should Know
Recommended Citation
Smati H, Qadeer YK, Rodriguez M, Moras E, Fonarow GC, Isaacs SD, Marwick TH, and Krittanawong C. Diabetic Cardiomyopathy: What Clinicians Should Know. Am J Med 2024.
Document Type
Article
Publication Date
3-1-2025
Publication Title
The American journal of medicine
Abstract
Diabetes has classically been associated with atherosclerotic cardiovascular disease. However, heart failure is now increasingly recognized as a prevalent and often first cardiovascular complication among patients with diabetes. Investigation of this epidemiological relationship has led to recognition of diabetic cardiomyopathy, or structural heart disease that develops in patients with diabetes and may lead to progressive heart failure independently of coronary artery disease or conventional cardiovascular risk factors such as hypertension. Despite increased awareness, clinical management of this common cardiovascular complication remains challenging, with no consensus on its diagnosis or treatment. The lack of specific therapy has been recognized as an unmet clinical need. In this review, we summarize current understanding of the hallmark metabolic and structural changes of diabetic cardiomyopathy, appraise current tools for diagnosis and staging among patients, and describe the emerging but still preclinical data on therapeutic options.
Medical Subject Headings
Humans; Diabetic Cardiomyopathies; Heart Failure
PubMed ID
39505128
ePublication
ePub ahead of print
Volume
138
Issue
3
First Page
387
Last Page
395
