Impact of patisiran on polyneuropathy of hereditary transthyretin amyloidosis in patients with a V122I or T60A variant: a phase IV multicenter study
Recommended Citation
Hussain Y, Malhotra S, Sperry BW, Shu F, Ananthasubramaniam K, Desai U, Egolum U, Fernandez J, Freimer M, Mauricio E, Quan D, Small R, Capocelli K, Roblin S, Bender S, Jay PY, Yureneva E, and Zolty R. Impact of patisiran on polyneuropathy of hereditary transthyretin amyloidosis in patients with a V122I or T60A variant: a phase IV multicenter study. Ann Med 2025;57(1):2537347.
Document Type
Article
Publication Date
12-1-2025
Publication Title
Annals of medicine
Abstract
BACKGROUND: This study assessed the effectiveness and safety of patisiran in patients with V122I/T60A variant transthyretin (ATTRv) amyloidosis with polyneuropathy. These variants have been under-represented in previous trials of gene-silencing agents.
METHODS: This was a multicenter, phase IV study conducted at 27 sites in the USA. Patients were ≥ 18 years, diagnosed with ATTRv amyloidosis with polyneuropathy and a documented V122I or T60A variant. Patisiran-treated patients were enrolled prospectively, ambispectively, and retrospectively. The primary endpoint was the proportion of patients with a stable or improved polyneuropathy disability (PND) score at 12 months vs. baseline. Safety was monitored throughout the trial.
RESULTS: Sixty-seven patients were enrolled, of whom 58 received ≥ 1 dose of patisiran. In the efficacy population, 42/45 (93.3%) patients demonstrated stable or improved PND scores from baseline to Month 12. Patients also showed stable or improved quality of life, health status, autonomic symptoms, and cardiac function vs. baseline. Adverse events occurred in 13/42 (31.0%) patients in the prospective and ambispective cohorts; most were mild or moderate. No deaths or cardiac hospitalizations were considered related to patisiran.
CONCLUSIONS: Patisiran demonstrated a consistent positive effect across multiple endpoints in patients with V122I/T60A ATTRv amyloidosis, including polyneuropathy manifestations.
Medical Subject Headings
Humans; Amyloid Neuropathies, Familial; Male; Female; Middle Aged; Polyneuropathies; Aged; Quality of Life; Prealbumin; Retrospective Studies; Treatment Outcome; Prospective Studies; Adult; Aged, 80 and over; RNA, Small Interfering
PubMed ID
40974604
Volume
57
Issue
1
First Page
2537347
Last Page
2537347
