Effects of supersaturated oxygen therapy on infarct size and microvascular obstruction following myocardial infarction: A systematic review and meta-analysis

Document Type

Article

Publication Date

3-1-2026

Publication Title

American heart journal

Keywords

Humans, Percutaneous Coronary Intervention, Oxygen Inhalation Therapy, ST Elevation Myocardial Infarction, Myocardial Infarction, Microcirculation, Oxygen

Abstract

BACKGROUND: Supersaturated oxygen (SSO₂) therapy is an emerging intervention to minimize myocardial damage and improve outcomes in patients with ST-segment elevation myocardial infarction (STEMI). This meta-analysis evaluated the efficacy of SSO₂ therapy to reduce infarct size and microvascular obstruction (MVO).

METHODS: PubMed, Embase, and Cochrane databases were systematically searched for studies comparing percutaneous coronary intervention (PCI) plus SSO(2) to PCI alone for STEMI. Outcomes of interest included infarct size, MVO, and subsequent major adverse cardiovascular events (MACE), all-cause mortality, re-infarction, and target vessel revascularization (TVR). Mean differences (MD) with 95% confidence intervals (CIs) were calculated using random-effects models.

RESULTS: Six studies (n=1660) were included with 548 patients (33%) receiving SSO₂ therapy. Pooled analysis showed that PCI plus SSO₂ significantly reduced infarct size (MD -4.31; 95% CI -6.70 to -1.92; p< 0.01) and MVO (SMD -0.72; 95% CI -1.11 to -0.34; p< 0.01) compared with PCI alone. MACE, all-cause mortality, re-infarction, and TVR were comparable between the groups.

CONCLUSION: SSO₂ therapy significantly reduced infarct size and MVO in patients undergoing PCI for STEMI.

Medical Subject Headings

Humans; Percutaneous Coronary Intervention; Oxygen Inhalation Therapy; ST Elevation Myocardial Infarction; Myocardial Infarction; Microcirculation; Oxygen

PubMed ID

41297689

ePublication

ePub ahead of print

Volume

293

First Page

107311

Last Page

107311

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