The Emerging Role of Lithotripsy in Structural Heart Interventions
Recommended Citation
Fang JX, Lai LKL, Giustino G, Khan JM, Engel Gonzalez P, O'Neill BP, Frisoli TM, Lee JC, Jabri A, Wang DD, O'Neill WW, and Villablanca PA. The Emerging Role of Lithotripsy in Structural Heart Interventions. Curr Cardiol Rep 2025;27(1):142.
Document Type
Article
Publication Date
10-14-2025
Publication Title
Current cardiology reports
Keywords
Humans, Lithotripsy, Heart Valve Diseases
Abstract
PURPOSE OF REVIEW: Lithotripsy, first applied to treating nephrolithiasis, has an evolving role in cardiovascular disease, including intravascular treatment of calcified coronary and peripheral artery disease. Its role is expanding to the management of valvular and structural heart disease. This narrative review provides an overview of the emerging role of lithotripsy in various valvular and structural heart interventions.
RECENT FINDINGS: We have conducted a comprehensive literature review of all publications on lithotripsy in structural heart interventions found in PubMed and Google Scholar. We have also included a series of case examples of lithotripsy in structural heart interventions from a tertiary referral center in the United States (Henry Ford Health, Michigan). Lithotripsy has been used to facilitate large-bore access in both transfemoral and alternative access procedures, to treat valvular stenosis of mitral and aortic valves, manage paravalvular leak closure, aid transcatheter electrosurgery, and manage endovascular, congenital, and structural electrophysiology procedures. While a nationwide registry is available for large-bore access facilitation, the current data on valvular stenosis is limited to a single-center registry. Data on most other applications is restricted to case reports and case series and is subject to publication bias. Only two studies have been published on ex vivo and translational models. Lithotripsy is increasingly used off-label in structural heart interventions, with early clinical successes being reported. Translational research and bench-testing models are necessary to determine the optimal energy transfer conditions for valvular and annular lithotripsy. Multi-center studies and randomized controlled trials are needed to assess the efficacy of these novel procedures.
Medical Subject Headings
Humans; Lithotripsy; Heart Valve Diseases
PubMed ID
41085773
Volume
27
Issue
1
First Page
142
Last Page
142
