Cardiac microcurrent therapy in heart failure: Mechanistic rationale, early clinical evidence, and future directions
Recommended Citation
Fudim M, Kallel F, Rame JEE, Butler J, Bax JJ, Drakos SG, Lanfear DE, Burkhoff D, Somesh DB, Zdravkovic M, Preradović TK, Tomovic M, Kosevic D, Abraham WT, Anker SD. Cardiac microcurrent therapy in heart failure: Mechanistic rationale, early clinical evidence, and future directions. Heart Fail Rev. 2026;31(1).
Document Type
Article
Publication Date
6-8-2026
Publication Title
Heart failure reviews
Keywords
Humans, Heart Failure, Ventricular Remodeling, Stroke Volume, Animals, Ventricular Function, Left, Electric Stimulation Therapy
Abstract
Despite major advances in guideline-directed medical therapy (GDMT), many patients with heart failure with reduced ejection fraction (HFrEF) remain symptomatic, with persistent limitations in functional capacity and health status, underscoring the need for adjunctive therapeutic strategies. Direct cardiac microcurrent (C-MIC) therapy is a non-excitatory bioelectrical intervention device to modulate myocardial remodeling rather than rhythm or acute contractility. C-MIC therapy influence myocardial biology, including pathways related to fibrosis, inflammation, and cellular homeostasis by delivering continuous, subthreshold direct current. Preclinical studies across cardiomyocytes, animal models, and cardiac fibroblasts suggest that microcurrent exposure may attenuate profibrotic signaling, regulate extracellular matrix turnover, and improve calcium handling, providing a mechanistic rationale for reverse remodeling. Early clinical experience, including first-in-human studies and a randomized trial in carefully selected patients with non-ischemic HFrEF, demonstrates feasibility and a consistent signal of improvement in left ventricular function, functional capacity, and patient-reported outcomes. However, the current evidence base remains limited by small sample size, open-label designs, and the absence of sham-controlled evaluation. All available clinical data are derived from surgically implanted systems, and the effectiveness of less invasive configurations remains uncertain. Accordingly, C-MIC should be considered an investigational therapy. Future development will require rigorous mechanistic validation, optimization of device programming and delivery parameters, and confirmation of efficacy in adequately powered, sham-controlled trials to define its role in contemporary HF management.
Medical Subject Headings
Humans; Heart Failure; Ventricular Remodeling; Stroke Volume; Animals; Ventricular Function, Left; Electric Stimulation Therapy
PubMed ID
42258045
Volume
31
Issue
1
