Percutaneous Impella RP use for refractory right heart failure in adolescents and young adults-A multicenter US experience
Recommended Citation
Qureshi AM, Turner ME, O'Neill W, Denfield SW, Aghili N, Badiye A, Gandhi R, Tehrani B, Chang G, Oyama JK, Sinha S, Brozzi N, and Morray B. Percutaneous Impella RP use for refractory right heart failure in adolescents and young adults-A multicenter U.S. experience. Catheter Cardiovasc Interv 2020.
Document Type
Article
Publication Date
3-4-2020
Publication Title
Catheterization and cardiovascular interventions
Abstract
OBJECTIVE: To assess the outcomes of the use of the percutaneous Impella RP device (Abiomed, Danvers, MA) in adolescents and young adults.
BACKGROUND: Results of the Impella RP device have been reported in adults, but a multicenter experience in adolescents and young adults has yet to be reported.
METHODS: Patients ≤21 years of age who underwent implantation of an Impella RP device for refractory right heart failure from June, 2016 to April, 2018 at nine U.S. Centers were included.
RESULTS: A total of 12 adolescents, median age of 18 (14-21) years and median weight 74.4 (49-112.4) kg underwent Impella RP implantation (INTERMACS Profile 1 in nine and Profile 2 in three patients. The central venous pressure decreased from 20 (16-35) to 12 (7-17) mmHg, (p = .001). One patient was concomitantly supported with an intra-aortic balloon pump (IABP) and the rest with a percutaneous/surgically placed left ventricular assist device. There was one adverse event related to the Impella RP device (thrombosis requiring explant). The support duration was 6.5 days (4.8 hr-18.4 days) and survival to hospital discharge was 83%. At a median follow-up of 11 months (5 days-2.5 years), 8 of 12 (67%) patients are alive.
CONCLUSIONS: In this multicenter experience, the Impella RP device was found to be efficacious and safe when used in adolescents and young adults. Further studies are warranted to identify suitable young/pediatric candidates for Impella RP therapy for right heart failure.
PubMed ID
32129576
ePublication
ePub ahead of print
