Recommended Citation
Gupta K, Pate M, Kakar TS, Di Carli MF, Ananthasubramaniam K, Prabhu SD, and Bajaj NS. NON-INVASIVE ASSESSMENT OF MYOCARDIAL ENERGETICS USING 11-C ACETATE POSITRON EMISSION TOMOGRAPHY: SYSTEMATIC REVIEW AND META-ANALYSIS. J Am Coll Cardiol 2022; 79(9):1321.
Document Type
Conference Proceeding
Publication Date
3-8-2022
Publication Title
J Am Coll Cardiol
Abstract
Background: 11-C acetate PET is a non-invasive imaging modality to assess myocardial oxygen consumption (MVO2), and external efficiency (MEE). We conducted a systematic review and meta-analysis of available literature on this topic.
Methods: We searched electronic databases from inception to September 15, 2021, for all studies using 11C-Acetate PET in humans and patients with CVD at rest. Data are presented as mean with 95% CI.
Results: 54 studies with 1,182 participants (337 healthy, 845 patients with any CVD) met our inclusion criteria. Mean MVO2 and MEE in studies with healthy controls was 0.11 (0.09, 0.13, I2=99.3%) ml min-1g-1 and 27% (22, 33 I2=98.3%), respectively (Figure). Mean MEE in HFrEF, HFpEF, AS and HCM was 15% (13, 18), 13% (12, 14), 23% (20, 25) and 19% (CI 17, 22), respectively. In HFrEF, both mean MVO2 (difference -0.02,-0.03, -0.01) and MEE (difference -9%, [-13, -6]) were lower vs. healthy controls. In HFpEF, mean MVO2 was higher (difference 0.03, -0.01, 0.07), but mean MEE was similar. In aortic stenosis, mean MVO2 was higher (difference 0.03, [0.01, 0.05]) and mean MEE lower (difference -7%, [-16, 1]) vs. healthy controls. In HCM, mean MVO2 was higher (WMD 0.01, [0.00, 0.02]), and mean MEE was lower (difference -21%, [-33, -8]).
Conclusion: Assessment of myocardial energetics using 11-C acetate PET can help understand the pathophysiology of distinct CVD. There is significant heterogeneity in the current literature, and there is an unmet need to standardize protocols and reporting methods.
Volume
79
Issue
9
First Page
1321
