Organ Care System Heart Perfusion (OHP) Registry Annual Report 2024 - Donation After Circulatory Death (DCD) Donors
Recommended Citation
Anyanwu AC, D'Alessandro D, Patel P, Shudo Y, Daneshmand M, Chan J, Couper G, Esmailian F, Peltz M, Itoh A, Takeda K, Malyala R, Lozonschi L, Klein L, Pal J, Shah A, Ohira S, Meyer D, Kilic A, Pham D, Haft J, Kaczorowski D, Selzman C, Villavicencio M, Funamoto M, Goldstein D, Gruber P, Sun B, Kai M, Skipper E. Organ Care System Heart Perfusion (OHP) Registry Annual Report 2024 - Donation After Circulatory Death (DCD) Donors. J Heart Lung Transplant 2025; 44(4):S667.
Document Type
Conference Proceeding
Publication Date
4-1-2025
Publication Title
J Heart Lung Transplant
Abstract
Purpose: DCD donation has significantly expanded the donor pool resulting in increased number of heart transplantations. In this study, we examine the outcomes of transplantation from donation after circulatory death (DCD) that used OCS comparing it with non-OCS DCD heart transplantations. Methods: DCD cohort from the OCS heart perfusion (OHP) registry constituted the OCS cohort. Organ Procurement and Transplantation Network (OPTN) database was used to identify DCD transplants from same centers during the same time period that were not supported on OCS, which constituted the non-OCS cohort. Donor and recipient characteristics and survival data was available from the OPTN database for both arms and these data were compared. OCS cohort was further analyzed by cases managed by the National OCS program (NOP) versus direct acquisition by the transplant center. Results: A total of 889 OCS DCD and 354 non-OCS DCD transplants were identified. The recipients in the OCS cohort were more likely to be on ventricular assist device at transplant (38.8% vs 28.2%), had longer distance between donor and recipient (449miles vs 304miles) and be in UNOS status 2 (45.8% vs 31.1%) and less likely to be in status 4 (20.4% vs 32.88%). The cross-clamp time duration on average was higher (379 min vs 226 min) and the ischemic time was shorter (112.7 min vs 226.8 min). Despite the recipient risk differences, 6-month and 1-year survival was similar in both cohorts (92.8% vs 92.5% and 90.4 vs 88.9%; p=0.844) Conclusion: OCS allows DCD hearts to be procured over longer distances, with longer cross-clamp times and also enables utilization for higher risk recipients, without compromise in 1 year post-transplant outcomes. OCS may, therefore, allow increased access to DCD transplantation, particular for the higher risk recipient and where the donor hospital is distant.
Volume
44
Issue
4
First Page
S667
