Quantitative Scoring Of Lung Perfusion Map From Dual Energy CT For Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Evaluation

Document Type

Conference Proceeding

Publication Date

7-1-2025

Publication Title

J Cardiovasc Comput Tomogr

Abstract

Introduction: ECG-gated DECT allows for one-stop evaluation of CTEPH patients, due to its capability to simultaneously map lung perfusion with spectral imaging and characterize RV anatomy and function with high spatiotemporal resolution. Evaluation of its created Pulmonary Blood Volume (PBV) map, however, is still largely based on visual assessment. We have developed and are presenting a novel quantitative scoring methodology. Methods: The method includes the following steps: (1) The DECT analysis application on a Siemens Syngo Via server were used to create lung PBV images and segment the lungs into 5 sub-volumes (3 on right, 2 on left). (2) for any lung sub-volume, the mean value and the standard deviation of HU enhancement from the PBV map are calculated and normalized into percentages with respect to the left atrium HU enhancement scaled by a constant; (3) with a starting value of 0, the score of each sub-volume increases by 1 if either its normalized mean value falls below 80% or its normalized standard deviation exceeds 40%. (4) the overall score is the sum of all sub-volumes. The method was tested on three clinical datasets acquired by dual-source DECT. Results: Scores of the three datasets show correlation with the extent and severity of the perfusion defects as visualized on the PBV images and match clinical imaging reports. Evaluation with more clinical datasets is ongoing. Conclusions: The proposed method shows potential for a simplified semi-automated quantification for clinical use. Quantitative PBV map scoring could enable more objective CTEPH evaluation and more streamlined workflow. [Formula presented] [Formula presented]

Volume

19

Issue

4

First Page

S65

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