TCT-977 Acute Effects of Transcatheter Tricuspid Valve Replacement on Right Heart Hemodynamics

Document Type

Conference Proceeding

Publication Date

10-28-2025

Publication Title

J Am Coll Cardiol

Abstract

Background: Current literature describes an increase in RV systolic volume following TTVI. We aimed to characterize the acute hemodynamic changes after TTVR using invasive measurements. Methods: This retrospective, single-center, descriptive study included 112 patients who underwent TTVR for severe TR between March 2023 and March 2025. Invasive hemodynamic measurements and echocardiogram were recorded before and after valve implantation. RV dysfunction was visually estimated using a four-point scale (none, mild, moderate, severe). Results: Significant increases were observed in RVSP (p<0.01), mean PA pressure (p<0.01), and PCWP (p<0.01) following TTVR. RV function declined significantly following TTVR (p<0.01), but improved at 30-day follow up (p=0.03). RV function was reduced at 30-days compared to baseline (p=0.02). PAPI showed a nonsignificant trend toward an increase while PVR (p=0.37), CO (p=0.59), and CI (p=0.78) remained unchanged. [Formula presented] Conclusion: TTVR is associated with an acute increase in right-sided filling pressures and a transient decline in RV function. By 30-days, RV function improves relative to the immediate post-TTVR period but remains reduced compared to baseline. A longer follow up will further describe RV recovery following TTVR. These findings highlight the value of invasive hemodynamic assessment in characterizing early physiological responses to TTVR and may inform future preprocedural preparation and risk stratification strategies, especially in those with advanced RV dysfunction. Categories: STRUCTURAL: Valvular Disease and Intervention: Tricuspid

Volume

86

Issue

17

First Page

B417

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