TCT-318 Stroke after TAVR - Impact on Clinical Outcome and Patient Reported Quality of Life (QoL): The Michigan Structural Heart Consortium (MISHC) Experience

Document Type

Conference Proceeding

Publication Date

10-28-2025

Publication Title

J Am Coll Cardiol

Abstract

Background: We evaluated the incidence, risk factors, and comparative outcomes of patients who experienced a stroke following TAVR versus those who did not, using a large cohort from MISHC. Methods: MISHC collects data on all TAVRs performed at 31 hospitals in Michigan. Demographic, clinical, and procedural characteristics—including QoL as measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ)—were summarized. Comparisons between stroke and non-stroke groups were performed. Inverse Probability of Treatment Weighting was applied to adjust for confounding variables. Results: Among 18,633 patients who underwent TAVR between 1/2016-1/2024, 332 (1.78%) experienced a stroke prior to discharge. Patients who suffered a stroke had significantly higher in-hospital, 30-day, and one-year mortality rates compared with those who did not (p < 0.001). Adjusted outcomes are shown (key figure). KCCQ scores at 30 days remained significantly lower in stroke patients and one-year scores trended lower. Other adjusted outcomes were significantly worse in the stroke cohort. [Formula presented] Conclusion: Stroke following TAVR is associated with significantly worse clinical outcomes, including increased short- and long-term mortality, prolonged hospitalization, greater healthcare utilization, and diminished QoL. Even after adjustment, stroke patients demonstrated persistently lower 30-day QoL scores, with a non-significant trend toward lower scores at one year. Further research is needed to refine stroke prevention strategies and develop targeted rehabilitation approaches to optimize post-stroke recovery and long-term QoL in this high-risk population. Categories: STRUCTURAL: Valvular Disease and Intervention: Aortic

Volume

86

Issue

17

First Page

B140

Last Page

B141

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