26-A-10078-ACC Ischemic Heart Disease and Opioid Related Mortality: Unveiling the Hidden Cardiovascular Consequences of the Opioid Epidemic (2000-2020)

Document Type

Conference Proceeding

Publication Date

4-7-2026

Publication Title

J Am Coll Cardiol

Abstract

Background: Opioid analgesics are potent analgesics. Nonetheless their misuse is rising and studies have shown increased cardiovascular risk and its associated mortality with Opioid use, emphasizing its growing impact on public health. Methods: This study used the CDC WONDER database to analyze ischemic heart disease IHD and opioid related mortality in the U.S from 2000 to 2020. ICD 10 codes were utilized to identify deaths related to IHD (120-125) and opioid related causes (F11,T40). Join point regression was used to calculate age adjusted mortality rates (AAMRs) and annual percentage change (APC) trends, results were stratified by age, sex, ethnicity and region. Results The study showed 37,404 opioid induced IHD deaths from 2000-2020. In 2020, males had a higher AAMR 1.5 than females 0.5. Racial subgroups showed Non Hispanic (NH) Black individuals had the highest APC: 28.3;95% CI:13.3-45.3; p=0.0008 in 2020. The Western U.S. had the highest regional AAMR 1.1, while urban areas had higher mortality than rural (AAMR 1.0 for urban areas) in 2020. West Virginia had the highest state level AAMR 2.2 in 2020. The 35-44 age group had the highest APC 22.4; p=0.022 in 2020. Most deaths occurred at home, accounting for 21,649 deaths from 2000-2020. Conclusion: Opioid induced IHD mortality varied by demographics and region, with males, NH Black individuals, the West and West Virginia were most affected. The highest death rate in adults aged 35-44 and at home deaths demands for urgent targeted public health interventions.

Volume

87

Issue

13

First Page

A838

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