Recommended Citation
Paternoster L, Standl M, Waage J, Baurecht H, Hotze M, Strachan DP, Curtin JA, Bønnelykke K, Tian C, Takahashi A, Esparza-Gordillo J, Alves AC, Thyssen JP, den Dekker HT, Ferreira MA, Altmaier E, Sleiman PM, Xiao F, Gonzalez JR, Marenholz I, Kalb B, Yanes M, Xu C, Carstensen L, Groen-Blokhuis MM, Venturini C, Pennell CE, Barton SJ, Levin AM, Curjuric I, Bustamante M, Kreiner-Møller E, Lockett GA, Bacelis J, Bunyavanich S, Myers RA, Matanovic A, Kumar A, Tung JY, Hirota T, Kubo M, McArdle WL, Henderson AJ, Kemp JP, Zheng J, Smith G, Rüschendorf F, Bauerfeind A, Lee-Kirsch M, Arnold A, Homuth G, Schmidt CO, Mangold E, Cichon S, Keil T, Rodríguez E, Peters A, Franke A, Lieb W, Novak N, Fölster-Holst R, Horikoshi M, Pekkanen J, Sebert S, Husemoen LL, Grarup N, de Jongste JC, Rivadeneira F, Hofman A, Jaddoe V, Pasmans S, Elbert NJ, Uitterlinden AG, Marks GB, Thompson PJ, Matheson MC, Robertson CF, Ried JS, Li J, Zuo X, Zheng X, Yin X, Sun L, McAleer MA, O'Regan G, Fahy C, Campbell LE, Macek M, Kurek M, Hu D, Eng C, Postma DS, Feenstra B, Geller F, Hottenga J, Middeldorp CM, Hysi P, Bataille V, Spector T, Tiesler C, Thiering E, Pahukasahasram B, Yang JJ, Imboden M, Huntsman S, Vilor-Tejedor N, Relton C, Myhre R, Nystad W, Custovic A, Weiss S, Meyers D, Söderhäll C, Melén E, Ober C, Raby B, Simpson A, Jacobsson B, Holloway J, Bisgaard H, Sunyer J, Hensch N, Williams KL, Godfrey K, Wang C, Boomsma D, Melbye M, Koppelman G, Jarvis D, McLean W, Irvine A, Zhang X, Hakonarson H, Gieger C, Burchard E, Martin N, Duijts L, Linneberg A, Jarvelin M, Noethen M, Lau S, Hübner N, Lee Y, Tamari M, Hinds D, Glass D, Brown S, Heinrich J, Evans D, Weidinger S. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics 2015; 47(12):1449-1456.
Document Type
Article
Publication Date
12-1-2015
Publication Title
Nature Genetics
Keywords
Case-Control Studies, Dermatitis, Atopic, Ethnic Groups, Genetic Loci, Genetic Markers, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Immunity, Innate, Polymorphism, Single Nucleotide, Risk Factors, T-Lymphocytes
Abstract
Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.
Medical Subject Headings
Case-Control Studies; Dermatitis, Atopic; Ethnic Groups; Genetic Loci; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Immunity, Innate; Polymorphism, Single Nucleotide; Risk Factors; T-Lymphocytes
PubMed ID
26482879
Volume
47
Issue
12
First Page
1449
Last Page
1456
