Title

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Authors

Lavinia Paternoster
Marie Standl
Johannes Waage
Hansjörg Baurecht
Melanie Hotze
David P Strachan
John A Curtin
Klaus Bønnelykke
Chao Tian
Atsushi Takahashi
Jorge Esparza-Gordillo
Alexessander Couto Alves
Jacob P Thyssen
Herman T den Dekker
Manuel A Ferreira
Elisabeth Altmaier
Patrick Ma Sleiman
Feng Li Xiao
Juan R Gonzalez
Ingo Marenholz
Birgit Kalb
Maria Pino Yanes
Cheng-Jian Xu
Lisbeth Carstensen
Maria M Groen-Blokhuis
Cristina Venturini
Craig E Pennell
Sheila J Barton
Albert M. Levin, Henry Ford Health SystemFollow
Ivan Curjuric
Mariona Bustamante
Eskil Kreiner-Møller
Gabrielle A Lockett
Jonas Bacelis
Supinda Bunyavanich
Rachel A Myers
Anja Matanovic
Ashish Kumar
Joyce Y Tung
Tomomitsu Hirota
Michiaki Kubo
Wendy L McArdle
A J Henderson
John P Kemp
Jie Zheng
George Davey Smith
Franz Rüschendorf
Anja Bauerfeind
Min Ae Lee-Kirsch
Andreas Arnold
Georg Homuth
Carsten O Schmidt
Elisabeth Mangold
Sven Cichon
Thomas Keil
Elke Rodríguez
Annette Peters
Andre Franke
Wolfgang Lieb
Natalija Novak
Regina Fölster-Holst
Momoko Horikoshi
Juha Pekkanen
Sylvain Sebert
Lise L Husemoen
Niels Grarup
Johan C de Jongste
Fernando Rivadeneira
Albert Hofman
Vincent Wv Jaddoe
Suzanne Gma Pasmans
Niels J Elbert
André G Uitterlinden
Guy B Marks
Philip J Thompson
Melanie C Matheson
Colin F Robertson
Australian Asthma Genetics Consortium (AAGC)
Janina S Ried
Jin Li
Xian Bo Zuo
Xiao Dong Zheng
Xian Yong Yin
Liang Dan Sun
Maeve A McAleer
Grainne M O'Regan
Caoimhe Mr Fahy
Linda E Campbell
Milan Macek
Michael Kurek
Donglei Hu
Celeste Eng
Dirkje S Postma
Bjarke Feenstra
Frank Geller
Jouke Jan Hottenga
Christel M Middeldorp
Pirro Hysi
Veronique Bataille
Tim Spector
Carla Mt Tiesler
Elisabeth Thiering
Badri Pahukasahasram
James J Yang
Medea Imboden
Scott Huntsman
Natàlia Vilor-Tejedor
Caroline L Relton
Ronny Myhre
Wenche Nystad
Adnan Custovic
Scott T Weiss
Deborah A Meyers
Cilla Söderhäll
Erik Melén
Carole Ober
Benjamin A Raby
Angela Simpson
Bo Jacobsson
John W Holloway
Hans Bisgaard
Jordi Sunyer
Nicole M Probst Hensch
Keoki L. Williams, Henry Ford Health SystemFollow
Keith M Godfrey
Carol A Wang
Dorret I Boomsma
Mads Melbye
Gerard H Koppelman
Deborah Jarvis
Wh Irwin McLean
Alan D Irvine
Xue Jun Zhang
Hakon Hakonarson
Christian Gieger
Esteban G Burchard
Nicholas G Martin
Liesbeth Duijts
Allan Linneberg
Marjo-Riitta Jarvelin
Markus M Noethen
Susanne Lau
Norbert Hübner
Young-Ae Lee
Mayumi Tamari
David A Hinds
Daniel Glass
Sara J Brown
Joachim Heinrich
David M Evans
Stephan Weidinger

Document Type

Article

Publication Date

12-1-2015

Publication Title

Nature Genetics

Abstract

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

Medical Subject Headings

Case-Control Studies; Dermatitis, Atopic; Ethnic Groups; Genetic Loci; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Immunity, Innate; Polymorphism, Single Nucleotide; Risk Factors; T-Lymphocytes

PubMed ID

26482879

Volume

47

Issue

12

First Page

1449

Last Page

1456

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