Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Recommended Citation
Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WO, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung K, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson J, Farrall M, Fedorova Y, Feenstra B, Ferreira M, Freidin M, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib S, Gilliland F, Granell R, Graves P, Gudbjartsson D, Haahtela T, Heckbert S, Heederik D, Heinrich J, Heliövaara M, Henderson J, Himes B, Hirose H, Hirschhorn J, Hofman A, Holt P, Hottenga J, Hudson T, Hui J, Imboden M, Ivanov V, Jaddoe V, James A, Janson C, Jarvelin M, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kähönen M, Kantor D, Karunas A, Khusnutdinova E, Koppelman G, Kozyrskyj A, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee Y, Lehtimäki T, Letort S, Levin A, Li G, Liang L, Loehr L, London S, Loth D, Manichaikul A, Marenholz I, Martinez F, Matheson M, Mathias R, Matsumoto K, Mbarek H, McArdle W, Melbye M, Melén E, Meyers D, Michel S, Mohamdi H, Musk A, Myers R, Nieuwenhuis M, Noguchi E, O'Connor G, Ogorodova L, Palmer C, Palotie A, Park J, Pennell C, Pershagen G, Polonikov A, Postma D, Probst-Hensch N, Puzyrev V, Raby B, Raitakari O, Ramasamy A, Rich S, Robertson C, Romieu I, Salam M, Salomaa V, Schlünssen V, Scott R, Selivanova P, Sigsgaard T, Simpson A, Siroux V, Smith L, Solodilova M, Standl M, Stefansson K, Strachan D, Stricker B, Takahashi A, Thompson P, Thorleifsson G, Thorsteinsdottir U, Tiesler C, Torgerson D, Tsunoda T, Uitterlinden A, van der Valk R, Vaysse A, Vedantam S, von Berg A, von Mutius E, Vonk J, Waage J, Wareham N, Weiss S, White W, Wickman M, Widén E, Willemsen G, Williams L, Wouters I, Yang J, Zhao J, Moffatt M, Ober C, Nicolae D. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nature genetics 2018; 50(1):42-53.
Document Type
Article
Publication Date
1-2018
Publication Title
Nature genetics
Abstract
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
PubMed ID
29273806
Volume
50
Issue
1
First Page
42
Last Page
53
