A Randomized, Controlled, Split-Face Study of the Efficacy of a Picosecond Laser in the Treatment of Melasma

Document Type

Article

Publication Date

11-1-2019

Publication Title

Journal of drugs in dermatology

Abstract

Introduction: Melasma is a common disorder where patients develop hyperpigmented macules and patches on the face and is thought to be the result of sun exposure and hormonal contributions, although the pathogenesis is not completely understood. Lasers have been used for melasma treatment with varying degrees of success.

Objectives: The objective of this study was to examine the safety and efficacy of a novel picosecond laser for the treatment of melasma.

Materials and Methods: Ten subjects received nine weekly laser treatments with a picosecond laser to a randomized half of their face. A lightening cream was applied to the entire face to serve as a control. The primary outcome measure was clinical efficacy measured by a patient-reported outcome survey, the Melasma Quality of Life (MELASQOL) questionnaire, and physician assessment with the Global Aesthetic Improvement Scale (GAIS). The secondary outcome measure was safety, which was assessed by monitoring for adverse events. Photos were taken before every treatment and at a 1-week follow-up.

Results: Ninety percent of subjects rated their melasma as at least slightly better, and 90% percent of subjects would recommend this laser treatment to others with melasma. MELASQoL questionnaire scores improved by an average of 5.7 points after laser treatment. Assessments by two board-certified dermatologists using the GAIS revealed an overall improvement in 80% of patients on the laser treatment side versus 20% on the control side. Side effects, including erythema and discomfort, were minimal and transient post-treatment.

Conclusions: This study suggests that picosecond laser treatments are a safe and efficacious way to treat melasma.

Medical Subject Headings

Adolescent; Adult; Aged; Facial Dermatoses; Female; Humans; Lasers, Solid-State; Male; Melanosis; Middle Aged; Prospective Studies; Quality of Life; Surveys and Questionnaires; Treatment Outcome; Young Adult

PubMed ID

31741350

Volume

18

Issue

11

First Page

1104

Last Page

1107

Find It @ Sladen

Share

COinS