A review of vitamin B12 in dermatology

Document Type

Article

Publication Date

2-1-2015

Publication Title

American journal of clinical dermatology

Abstract

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry and metabolism of cobalamin is complex, and diseases can be associated with alterations of this metabolic pathway. The cutaneous manifestations of cobalamin deficiency include hyperpigmentation (most commonly); hair and nail changes; and oral changes, including glossitis. Additionally, several dermatologic conditions, including vitiligo, aphthous stomatitis, atopic dermatitis, and acne are related to cobalamin excess or deficiency. The cutaneous complications of cobalamin therapy include acne, rosacea, and allergic site reactions, or anaphylaxis with cobalamin injections. As cobalt is a component of cobalamin, patients with cobalt sensitivity have been reported to have cutaneous manifestations when receiving cobalamin replacement therapy.

Medical Subject Headings

Animals; Cobalt; Humans; Skin Diseases; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex

PubMed ID

25559140

Volume

16

Issue

1

First Page

27

Last Page

33

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