An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits

Authors

P. Isedeh, Henry Ford Health
Indermeet Kohli, Henry Ford HealthFollow
Mohammed Al-Jamal, Henry Ford Health
O. N. Agbai
M. Chaffins
Suneetha Devpura, Henry Ford HealthFollow
Meredith Mahan, Henry Ford HealthFollow
G. Vanderover
Henry W. Lim, Henry Ford HealthFollow
M. S. Matsui
Iltefat H. Hamzavi, Henry Ford HealthFollow

Recommended Citation

Isedeh P, Kohli I, Al-Jamal M, Agbai ON, Chaffins M, Devpura S, Mahan M, Vanderover G, Lim HW, Matsui MS, Hamzavi IH. An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits. The British journal of dermatology 2016; 174(4):862-868.

Document Type

Article

Publication Date

4-1-2016

Publication Title

The British journal of dermatology

Abstract

BACKGROUND: Acne vulgaris is a common condition that occurs in all skin types. Postinflammatory hyperpigmentation (PIH) is often associated with acne in patients of darker skin types, making it a common complaint in dermatology offices. Despite this, there is limited understanding of and effective treatment options for PIH.

OBJECTIVES: The study objective was to validate an in vivo model for PIH and to compare the clinical, histological and spectroscopic characteristics of artificially induced PIH and acne-induced PIH.

METHODS: A nonblinded, nonrandomized pilot study was performed. Thirty subjects served as their own control in which four sites treated with 35% trichloroacetic acid (TCA) solution and four truncal acne pustules were followed for 8 weeks and were evaluated clinically and histologically, and by colorimetry and spectroscopy.

RESULTS: The initial phases of inflammation between TCA- and acne-induced PIH differ. However, clinical evaluations were similar on and after day 14. Acne- and TCA-induced lesions were clinically, histologically and spectroscopically indistinguishable at day 28.

CONCLUSIONS: Clinical, spectroscopic and histological similarities of acne-induced and TCA-induced PIH at day 28 suggest that TCA-induced PIH can be a reproducible model for the study of acne-induced PIH.

Medical Subject Headings

Acne Vulgaris; Adolescent; Adult; Case-Control Studies; Caustics; Colorimetry; Erythema; Humans; Hyperpigmentation; Middle Aged; Models, Biological; Pilot Projects; Spectrum Analysis; Trichloroacetic Acid; Young Adult

PubMed ID

26663029

Volume

174

Issue

4

First Page

862

Last Page

868